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SUCCINYL CHOLINE (ANECTINE)

Class
Description
Onset and Duration
Indications
Contraindications
Adverse Reactions
Drug Interactions
How Supplied
Dosage and Administration
Special Considerations


SUCCINYL CHOLINE (ANECTINE)
Class

Neuromuscular blocker (depolarizing)


SUCCINYL CHOLINE (ANECTINE)
Description

Succinyl Choline has the briefest duration of action of all neuromuscular blocking drugs, making it a drug of choice for such procedures as terminating laryngospasm, endotracheal intubation, and electroconvulsive shock therapy. Like nondepolarizing blockers, depolarizing drugs also bind to the receptors for acetylcholine. However, because they cause depolarization of the muscle membrane, they often lead to fasciculations and some muscular contractions.


SUCCINYL CHOLINE (ANECTINE)
Onset & Duration

Onset:
Less than 1 min
Duration:
5 min

SUCCINYL CHOLINE (ANECTINE)
Indications

To facilitate intubation
To terminate laryngospasm
For muscle relaxation


SUCCINYL CHOLINE (ANECTINE)
Contraindications

Penetrating eye injury (succinyl choline increases intraocular pressure)
Inability to control airway or support ventilations with oxygen and positive pressure


SUCCINYL CHOLINE (ANECTINE)
Adverse Reactions

Hypotension
Bradycardias
Dysrhythmias
Initial muscle fasciculation
Excessive salivation
Malignant hyperthermia
Allergic reaction
Can exacerbate hyperkalemia in trauma patients (hours posttrauma)


SUCCINYL CHOLINE (ANECTINE)
Drug Interactions

Oxytocin, beta blockers, and organophosphates may potentiate effects.
Diazepam may reduce duration of action.
Cardiac glycosides may induce dysrhythmias.


SUCCINYL CHOLINE (ANECTINE)
How Supplied

40 mg in 2-ml ampule (20 mg/ml)
100 mg in 5-ml ampule (20 mg/ml)
Multidose vial


SUCCINYL CHOLINE (ANECTINE)
Dosage and Administration

Adult:
1.5 mg/kg rapid IV; repeat once if needed
Pediatric:
1 mg/kg dose rapid IV; repeat once if needed

SUCCINYL CHOLINE (ANECTINE)
Special Considerations

Pregnancy safety: Category C.
Carefully monitor the patient and be prepared to resuscitate.
Administer with caution to patients with severe trauma, burns, and electrolvte imbalances (high potassium levels).
Brain or spinal cord injury may prolong effects.
Children are not as sensitive to succinyl choline on a weight basis as adults and may require higher doses.
Succinyl choline has no effect on consciousness or pain.
Will not stop neuronal seizure activity.