Class
Description
Onset and Duration
Indications
Contraindications
Adverse Reactions
Drug Interactions
How Supplied
Dosage and Administration
Special Considerations
Vitamin (B1)
Thiamine combines with ATP to form thiamine pyrophosphate coenzyme, a necessary component for carbohydrate metabolism. Most vitamins required by the body are obtained through diet, but certain states, such as alcoholism and malnourishment, may affect the intake, absorption, and use of thiamine. The brain is extremely sensitive to thiamine deficiency.
Coma of unknown origin (before the administration of dextrose 50%, or Naloxone)
Delirium tremens
Beriberi (rare)
Wernicke's encephalopathy
There are no significant drug interactions with other emergency medications.
Hypotension (from rapid injection or large dose)
Anxiety
Diaphoresis
Nausea and vomiting
Allergic reaction (usually from IV injection; very rare)
There are no significant drug interactions with other emergency medications.
1000 mg in 10-ml vial (100 mg/ml)
Pregnancy safety: Category A.
Large IV doses may cause respiratory difficulties.
Anaphylactic reactions have been reported.