Class
Description
Onset and Duration
Indications
Contraindications
Adverse Reactions
Drug Interactions
How Supplied
Dosage and Administration
Special Considerations
Short-acting benzodiazepine CNS depressant
Midazolam HCl is a water-soluble benzodiazepine that may be administered for conscious sedation to relieve apprehension or impair memory before endotracheal or nasotracheal intubation.
Premedication for tracheal intubation
Hypersensitivity to midazolam
Glaucoma
Shock
Coma
Alcohol intoxication
Overdose
Depressed vital signs
Concomitant use of barbiturates, alcohol, narcotics, or other CNS depressants
Hiccough
Cough
Oversedation
Pain at the injection site
Nausea and vomiting
Headache
Blurred vision
Fluctuations in vital signs
Hypotension
Respiratory depression
Respiratory arrest
Sedative effect of midazolam may be accentuated by concomitant use of barbiturates, alcohol, or narcotics (it should therefore not be used in patients who have taken CNS depressants).
2-, 5-,10-ml vials (1 mg/ml)
1-, 2-, 5-,10-ml vials (5 mg/ml)
Pregnancy safety: Category D.
Administer immediately before the intubation procedure.
Provide continuous monitoring of respiratory and cardiac function.
Have resuscitation equipment and medication readily at hand. Never administer medication as IV bolus.