Onset and Duration
Dosage and Administration
Short-acting benzodiazepine CNS depressant
Midazolam HCl is a water-soluble benzodiazepine that may be administered for conscious sedation to relieve apprehension or impair memory before endotracheal or nasotracheal intubation.
Premedication for tracheal intubation
Hypersensitivity to midazolam
Depressed vital signs
Concomitant use of barbiturates, alcohol, narcotics, or other CNS depressants
Pain at the injection site
Nausea and vomiting
Fluctuations in vital signs
Sedative effect of midazolam may be accentuated by concomitant use of barbiturates, alcohol, or narcotics (it should therefore not be used in patients who have taken CNS depressants).
2-, 5-,10-ml vials (1 mg/ml)
1-, 2-, 5-,10-ml vials (5 mg/ml)
Pregnancy safety: Category D.
Administer immediately before the intubation procedure.
Provide continuous monitoring of respiratory and cardiac function.
Have resuscitation equipment and medication readily at hand. Never administer medication as IV bolus.