Picture

LABETALOL (NORMODYNE, TRANDATE)

Class
Description
Onset and Duration
Indications
Contraindications
Adverse Reactions
Drug Interactions
How Supplied
Dosage and Administration
Special Considerations


LABETALOL (NORMODYNE, TRANDATE)
Class

Alpha- and beta-adrenergic blocker


LABETALOL (NORMODYNE, TRANDATE)
Description

Labetalol is a competitive alpha1-receptor blocker as well as a nonselective beta-receptor blocker used to lower blood pressure in a hypertensive crisis. Because of alpha- and beta-blocking properties, blood pressure is reduced without reflex tachycardia, and total peripheral resistance is decreased without a significant alteration in cardiac output. In emergency care, labetalol is administered intravenously.


LABETALOL (NORMODYNE, TRANDATE)
Onset & Duration

Onset:
Within 5 min
Duration:
3-6 hr

LABETALOL (NORMODYNE, TRANDATE)
Indications

Hypertension


LABETALOL (NORMODYNE, TRANDATE)
Contraindications

Bronchial asthma
Congestive heart failure
Second- and third-degree heart block
Bradycardia
Cardiogenic shock


LABETALOL (NORMODYNE, TRANDATE)
Adverse Reactions

Headache
Dizziness
Ventricular dysrhythmias
Hypotension
Dyspnea
Allergic reaction
Facial flushing
Diaphoresis
Postural hypotension


LABETALOL (NORMODYNE, TRANDATE)
Drug Interactions

Bronchodilator effects of beta-adrenergic agonists may be blunted bv labetalol.
Nitroglycerin may augment hypotensive effects.


LABETALOL (NORMODYNE, TRANDATE)
How Supplied

100 mg in 20 ml of solvent ampule (5 mg/ml)


LABETALOL (NORMODYNE, TRANDATE)
Dosage and Administration

Adult:
5-20 mg slow IV over 2 min; additional injections of 1 0-40 mg can be given at 1 0-min intervals prn

Infusion: Mix 200 mg in 250 ml D5W (0.8 mg/ml); infuse at a rate of 2 mg/min, titrated to supine blood pressure.
Pediatric:
Safety has not been established.

LABETALOL (NORMODYNE, TRANDATE)
Special Considerations

Pregnancy safety: Category C.

Blood pressure, pulse rate, ECG should be continuously monitored. Observe for signs of congestive heart failure, bradycardia, bronchospasm. Labetalol should only be administered with the patient in a supine position.