Onset and Duration
Dosage and Administration
Carbohydrate, hypertonic solution
The term dextrose is used to describe the six-carbon sugar d-glucose, the principal form of carbohydrate used by the body. D50 is used in emergency care to treat hypoglycemia and to manage coma of unknown origin.
Altered level of consciousness
Coma of unknown etiology
Seizure of unknown etiology
Refractory cardiac arrest (controversial)
There are no significant contraindications for IV administration of 50% dextrose in emergency care.
Warmth, pain, burning from medication infusion, thrombophlebitis, rhabdomyositis
There are no significant drug interactions with other emergency medications.
25 g/50 ml prefilled syringe (500 mg/ml)
Pregnancy safety: NA
Draw blood sample before administration if possible.
Use blood-glucose reagent strips (Dextrostix) or glucometer before administration if possible.
Extravasation may cause tissue necrosis; use a large vein and aspirate occasionally to ensure route patency.
D50 sometimes precipitates severe neurological symptoms (Wernicke's encephalopathy) in thiamine-deficient patients such as alcoholics. (This can be prevented by administering 100 mg of thiamine, IV.)