Onset and Duration
Dosage and Administration
Synthetic opioid antagonist
Naloxone is a competitive narcotic antagonist used in the management and reversal of overdoses caused by narcotics and synthetic narcotic agents. Unlike other narcotic antagonists, which do not completely inhibit the analgesic properties of opiates, naloxone antagonizes all actions of morphine.
Decreased level of consciousness
Coma of unknown origin
Circulatory support in refractory shock (investigational)
Use with caution in narcotic-dependent patients who may experience withdrawal syndrome (including neonates of narcotic- dependent mothers)
Nausea and vomiting
Is incompatible with bisulfite and with alkaline solutions.
0.02 mg/ml (neonate), 0.4 mg/ml, 1 mg/ml
Pregnancy safety: Category B.
Seizures have been reported (no causal relationship established ).
May not reverse hypotension.
Caution should be exercised when administering naloxone to narcotic addicts (may precipitate withdrawal with hypertension, tachycardia, and violent behavior).