Class
Description
Onset and Duration
Indications
Contraindications
Adverse Reactions
Drug Interactions
How Supplied
Dosage and Administration
Special Considerations
Synthetic opioid antagonist
Naloxone is a competitive narcotic antagonist used in the management and reversal of overdoses caused by narcotics and synthetic narcotic agents. Unlike other narcotic antagonists, which do not completely inhibit the analgesic properties of opiates, naloxone antagonizes all actions of morphine.
Decreased level of consciousness
Coma of unknown origin
Circulatory support in refractory shock (investigational)
Hypersensitivity
Use with caution in narcotic-dependent patients who may experience withdrawal syndrome (including neonates of narcotic-
dependent mothers)
Tachycardia
Hypertension
Dysrhythmias
Nausea and vomiting
Diaphoresis
Is incompatible with bisulfite and with alkaline solutions.
0.02 mg/ml (neonate), 0.4 mg/ml, 1 mg/ml
Pregnancy safety: Category B.
Seizures have been reported (no causal relationship established ).
May not reverse hypotension.
Caution should be exercised when administering naloxone to narcotic addicts (may precipitate withdrawal with hypertension,
tachycardia, and violent behavior).